HEPARIN DERIVATIVES

Heparin is a complex polysaccharide composed of repeating disaccharides of uronic acid -> glucosamine. The disaccharide units may be biosynthetically modified as N-acetyl or N-sulfate glucosamine, 2-O-sulfate uronic acid and 6-O-sulfate and/or 3-O-sulfate glucosamine. Heparin Derivatives consist of a group of products derived from heparin, made by one or more chemical modifications. The modifications are designed to change the activity of relevant groups of the molecules, thus to provide a wide range of heparin derivatives for structure-function study and biological activity analysis.

 

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Over Sulfated Heparin

( Catalog No. GT6020 )

Over Sulfated Heparin is a derivative in which all primary hydroxyls in glucosamine residues and a large proportion of secondary hydroxyl groups in disaccharide units have been substituted by O-sulfate esters.

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Carboxyl-Reduced Heparin

( Catalog No. GT6060 )

Carboxyl-Reduced Heparin is a derivative in which the carboxyl group of uronic acid residues of heparin have been reduced to alcohols. The disaccharide units in the derivative are either glucose -> glucosamine or idose -> glucosamine.

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Periodate-Oxidized Heparin

( Catalog No. GT6070 )

Periodate-Oxidized Heparin is a derivative in which all unsulfated uronic acid residues of heparin are oxidized by periodic acid. After periodate oxidation the newly formed aldehydes are reduced to primary alcohols.

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Fully De-O-Sulfated Heparin

( Catalog No. GT6011 )

De-O-Sulfated Heparin is a derivative in which all O-sulfate esters of heparin have been removed without changing the backbone structure. Most of the negative charge contributed by O-sulfates has been eliminated.

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2-O-Desulfated Heparin

( Catalog No. GT6012 )

2-O-Desulfated Heparin is a derivative in which only the O-sulfate groups on C-2 of uronic acid residues have been removed. The backbone structure of the derivative is unchanged but all uronic acid residues become unsubstituted.

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6-O-Desulfated Heparin

( Catalog No. GT6013 )

6-O-Desulfated Heparin is a derivative in which most of O-sulfate groups on C-6 of glucosamine residues have been removed while most of the 2-O-sulfate / 3-O-sulfate groups are remain intact.

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Fully N-Acetylated Heparin

( Catalog No. GT6031 )

Fully N-Acetylated Heparin is a heparin derivative prepared by N-acetylation of De-N-Sulfated Heparin. All disaccharide units in the derivative are uronic acid -> N-acetyl-glucosamine units.

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Fully N-Sulfated Heparin

( Catalog No. GT6041 )

Fully N-Sulfated Heparin is a derivative made by N-sulfation of De-N-Acetylated Heparin. The sequence of the disaccharide units in the derivative are exclusively uronic acid -> N-sulfate-glucosamine.

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De-N-Sulfated Heparin

( Catalog No. GT6030 )

De-N-Sulfated Heparin is a derivative in which N-sulfate groups of the N-sulfated-glucosamine residues of heparin are removed. The altered disaccharide residues in the derivative become uronic acid -> glucosamine, while the unmodified disaccharide units remain as uronic acid -> N - acetyl-glucosamine.

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De-N-Acetylated Heparin

( Catalog No. GT6040 )

De-N-Acetylated Heparin is a heparin derivative in which all N-acetyl groups of the N-acetyl-glucosamine residues of heparin have been depleted. The altered disaccharide unit in the derivative becomes uronic acid -> glucosamine while the unmodified disaccharide unit remains as uronic acid -> N-sulfate-glucosamine.

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